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Synlett 1994; 1994(1): 46-48
DOI: 10.1055/s-1994-22733
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Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 4. Synthesis of the C37-C54 Subunit via Stereoselective Construction of Three Consecutive J, K, and L Rings

K. Horita* , Y. Sakurai, M. Nagasawa, K. Maeno, S. Hachiya, O. Yonemitsu
  • *Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060, Japan
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Publication Date:
22 March 2002 (online)

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A stereoselective synthesis of the C37-C54 subunit of halichondrin B via coupling between the C38-C43 fragment starting from D-tartaric acid and the C44-C54 fragment strating from L-tartaric acid is reported. Construction of three consecutive J, K, and L rings and introduction of asymmetric centers at C51 and C53 were important steps.